1957: Sanskrit Commission Recommended for Establishment of Sanskrit Institution.

1961: Kendriya Sanskrit Vidyapeetha Society, Tirupati Constituted 

1962: Foundation Stone Laid by the then Vice-President of India  Dr.S.Radhakrishnan on fourth January

Forty two acres of land leased out by the Tirumala Tirupati Desvasthanams (TTD) Trust, then headed by Executive Officer, Dr.C.Anna Rao along with a munificient donation of Rs.10 lacs towards construction of buildings.

1971: Kendriya Sanskrit Vidyapeetha came under the aegis of Rashtriya Sanskrit  Sansthan– an autonomous body under the                           Ministry of Education in April 1971

1987: Elevated its status to that of a Deemed University the Name was Changed as Rashtriya Sanskrit vidhyapeetha.

During the Silver Jubilee celebrations in 1987, Sri P.V.Narasimha Rao, the then  Union Minister of Human Resource Development, Govt. of India announced the decision of the Government to elevated its status to that of a Deemed University.

1989- The Deemed University was formally inaugurated by the then President of India Sri R. Venkataraman on 26th August, 1989.

1991-92: The Vidyapeetha started functioning as a Deemed University from the academic year

2020: Elevated its status to that of a Central University from April 30, 2020. The Name is Changed as  National Sanskrit University 

SL.No
CHAIRMAN/ DIRECTOR
From – To
01 Sri Patanjali Sastry,       former Chief Justice of India
02 Prof.V.Raghavan,       a reputed Indologist
03 Sri M.Ananthasayanam Ayyangar,       former Speaker of Lok Sabha.
04 Dr. B.R. Sharma 1962 to 1970.
PRINCIPAL
01 Sri Venkata Raghavacharya,
02 Dr.Mandan Mishra
03 Dr.R.Karunakaran
04 Dr. M.D. Balasubramanyam
05 Prof. N.S. Ramanuja Tatacharya
SL.No
CHANCELLOR
From-To
01 M.M.Sri Pattabhirama Sastri
02 Prof.Ramaranjan Mukherjee
03 Dr.V.R.Panchamukhi
04 Dr. J.B.Pattnaik
05 N.Gopalaswami I.A.S(Retd.)
VICE- CHANCELLOR
01 Prof. N.S. Ramanuja Tatacharya
02 Prof.S.B.Raghunathacharya
03 Prof.D.Prahladachar
04 Prof. Harekrishna Satapathy 2006-2015
05 Prof. V.Muralidhara Sharma Jan 2017-Jan 2022
05 Prof. Radhakant Thakur Jan 2022- till Date